Macrophage cholesterol efflux is a central step in reverse cholesterol transport, which helps to maintain cholesterol homeostasis and to reduce atherosclerosis. Lipophagy has recently been identified as a new step in cholesterol ester hydrolysis that regulates cholesterol efflux, since it mobilizes cholesterol from lipid droplets of macrophages via autophagy and lysosomes. In this review, we briefly discuss recent advances regarding the mechanisms of the cholesterol efflux pathway in macrophage foam cells, and present lipophagy as a therapeutic target in the treatment of atherosclerosis.

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• Bile salt signaling and bile salt-based therapies in cardiometabolic disease
  Claire C.J. Groenen, Thuc-Anh Nguyen, Coen C. Paulusma, Stan F.J. van de Graaf
  Clinical Science.2024; 138(1): 1.     CrossRef
• Huazhuotongmai decoction exerts anti-atherosclerotic effects by modulating the expression of ABCA1/SR-B1/PPAR-γ in vivo and in vitro
  Ya-ru Yan, Zi-jun Jia, Ya Wang, Feng-qin Xu, Qing-bing Zhou
  Phytomedicine Plus.2023; 3(2): 100436.     CrossRef
• The SGLT2 Inhibitor Canagliflozin Reduces Atherosclerosis by Enhancing Macrophage Autophagy
  Hongping Chen, Da Teng, Bowen Xu, Chunxiao Wang, Hua Wang, Wenjuan Jia, Lei Gong, Haibin Dong, Lin Zhong, Jun Yang
  Journal of Cardiovascular Translational Research.2023; 16(5): 999.     CrossRef
• FURIN suppresses the progression of atherosclerosis by promoting macrophage autophagy
  Hongping Chen, Lihui Zhang, Shaohua Mi, Hua Wang, Chunxiao Wang, Wenjuan Jia, Lei Gong, Haibin Dong, Bowen Xu, Yanyan Jing, Peipei Ge, Zhigang Pei, Lin Zhong, Jun Yang
  The FASEB Journal.2023;[Epub]     CrossRef
• Unbalanced Redox With Autophagy in Cardiovascular Disease
  Se-Jin Jeong, Goo Taeg Oh
  Journal of Lipid and Atherosclerosis.2023; 12(2): 132.     CrossRef
• Edible Bird’s Nest Effectively Attenuates Atherosclerosis through Modulation of Cholesterol Metabolism via Activation of PPARγ/LXRα Signaling Pathway In Vivo
  Nurul Nadiah Mohamad Nasir, Ramlah Mohamad Ibrahim, Rozi Mahmud, Nor Asma Ab Razak, Norsharina Ismail, Kim Wei Chan, Md Zuki Abu Bakar, Akhilesh K. Verma
  Journal of Food Biochemistry.2023; 2023: 1.     CrossRef
• The mitochondrial translocator protein (TSPO, 18 kDa): A key multifunctional molecule in liver diseases
  Yuchang Li, Liting Chen, Vassilios Papadopoulos
  Biochimie.2023;[Epub]     CrossRef
• The Differential Metabolomes in Cumulus and Mural Granulosa Cells from Human Preovulatory Follicles
  Er-Meng Gao, Bongkoch Turathum, Ling Wang, Di Zhang, Yu-Bing Liu, Rong-Xin Tang, Ri-Cheng Chian
  Reproductive Sciences.2022; 29(4): 1343.     CrossRef
• PHLPP1 promotes neutral lipid accumulation through AMPK/ChREBP-dependent lipid uptake and fatty acid synthesis pathways
  Keerthana Balamurugan, Raghavender Medishetti, Jyothi Kotha, Parameshwar Behera, Kanika Chandra, Vijay Aditya Mavuduru, Manjunath B. Joshi, Ramesh Samineni, Madhumohan R. Katika, Writoban Basu Ball, Manjunatha Thondamal, Anil Challa, Kiranam Chatti, Kisho
  iScience.2022; 25(2): 103766.     CrossRef
• Hydrochloride Berberine ameliorates alcohol-induced liver injury by regulating inflammation and lipid metabolism
  Xiumei Ke, Ruoyu Zhang, Pan Li, Ling Zuo, Meng Wang, Junxuan Yang, Jianwei Wang
  Biochemical and Biophysical Research Communications.2022; 610: 49.     CrossRef
• Metabolic Regulation of Macrophage Activation
  Ourania Kolliniati, Eleftheria Ieronymaki, Eleni Vergadi, Christos Tsatsanis
  Journal of Innate Immunity.2022; 14(1): 51.     CrossRef
• Emerging Roles of Lipophagy in Cancer Metastasis
  Haimeng Yin, Ying Shan, Tian Xia, Yan Ji, Ling Yuan, Yiwen You, Bo You
  Cancers.2022; 14(18): 4526.     CrossRef
• Genetic Factors for Coronary Heart Disease and Their Mechanisms: A Meta-Analysis and Comprehensive Review of Common Variants from Genome-Wide Association Studies
  Khairul Anwar Zarkasi, Noraidatulakma Abdullah, Nor Azian Abdul Murad, Norfazilah Ahmad, Rahman Jamal
  Diagnostics.2022; 12(10): 2561.     CrossRef
• Caveolin-1 in autophagy: A potential therapeutic target in atherosclerosis
  Kai Hou, Shuai Li, Meng Zhang, Xuping Qin
  Clinica Chimica Acta.2021; 513: 25.     CrossRef
• Contradictory regulation of macrophages on atherosclerosis based on polarization, death and autophagy
  Jing Zhang, Chuan-Rui Ma, Yun-Qing Hua, Lan Li, Jing-Yu Ni, Yu-Ting Huang, Sophia Esi Duncan, Sheng Li, Shan Gao, Guan-Wei Fan
  Life Sciences.2021; 276: 118957.     CrossRef
• A meta-analysis of HDL cholesterol efflux capacity and concentration in patients with rheumatoid arthritis
  Binbin Xie, Jiang He, Yong Liu, Ting Liu, Chaoqun Liu
  Lipids in Health and Disease.2021;[Epub]     CrossRef
• Rosmarinic Acid Increases Macrophage Cholesterol Efflux through Regulation of ABCA1 and ABCG1 in Different Mechanisms
  Jean-Baptiste Nyandwi, Young Shin Ko, Hana Jin, Seung Pil Yun, Sang Won Park, Hye Jung Kim
  International Journal of Molecular Sciences.2021; 22(16): 8791.     CrossRef
• FGF21 induces autophagy‐mediated cholesterol efflux to inhibit atherogenesis via RACK1 up‐regulation
  Lin Xiaolong, Guo Dongmin, Mihua Liu, Wang Zuo, Hu Huijun, Tan Qiufen, Hu XueMei, Lin Wensheng, Pan Yuping, Lin Jun, Zeng Zhaolin
  Journal of Cellular and Molecular Medicine.2020; 24(9): 4992.     CrossRef
• Lipophagy in atherosclerosis
  Qing Liu, Yuan-Mei Wang, Hong-Feng Gu
  Clinica Chimica Acta.2020; 511: 208.     CrossRef
• Lysosomotropic Features and Autophagy Modulators among Medical Drugs: Evaluation of Their Role in Pathologies
  Tatiana A. Korolenko, Thomas P. Johnston, Vaclav Vetvicka
  Molecules.2020; 25(21): 5052.     CrossRef
• LncRNA MALAT1 Enhances ox-LDL-Induced Autophagy through the SIRT1/MAPK/NF-κB Pathway in Macrophages
  Jiaqi Yang, Xuze Lin , Liangshan Wang, Tienan Sun, Qi Zhao, Qian Ma, Yujie Zhou
  Current Vascular Pharmacology.2020; 18(6): 652.     CrossRef
• CTRP13 inhibits atherosclerosis via autophagy‐lysosome‐dependent degradation of CD36
  Cheng Wang, Wenjing Xu, Minglu Liang, Dan Huang, Kai Huang
  The FASEB Journal.2019; 33(2): 2290.     CrossRef
• Subclinical atherosclerosis and its progression are modulated by PLIN2 through a feed‐forward loop between LXR and autophagy
  P. Saliba‐Gustafsson, M. Pedrelli, K. Gertow, O. Werngren, V. Janas, S. Pourteymour, D. Baldassarre, E. Tremoli, F. Veglia, R. Rauramaa, A.J. Smit, P. Giral, S. Kurl, M. Pirro, U. de Faire, S.E. Humphries, A. Hamsten, I. Gonçalves, M. Orho‐Melander, A. Fr
  Journal of Internal Medicine.2019; 286(6): 660.     CrossRef
• PCSK9: A new participant in lipophagy in regulating atherosclerosis?
  Jun Xiao, Yi-Min Deng, Xiang-Rui Liu, Jian-Ping Cao, Min Zhou, Ya-Ling Tang, Wen-Hao Xiong, Zhi-Sheng Jiang, Zhi-Han Tang, Lu-Shan Liu
  Clinica Chimica Acta.2019; 495: 358.     CrossRef
• Autophagy-Mediated Cholesterol Trafficking Controls Steroid Production
  Michael J. Texada, Alina Malita, Christian F. Christensen, Kathrine B. Dall, Nils J. Faergeman, Stanislav Nagy, Kenneth A. Halberg, Kim Rewitz
  Developmental Cell.2019; 48(5): 659.     CrossRef
• Lipophagy in nonliver tissues and some related diseases: Pathogenic and therapeutic implications
  Kebing Zhou, Pingbo Yao, Jun He, Hong Zhao
  Journal of Cellular Physiology.2019; 234(6): 7938.     CrossRef
• Autophagy differentially regulates macrophage lipid handling depending on the lipid substrate (oleic acid vs. acetylated-LDL) and inflammatory activation state
  Sapir Hadadi-Bechor, Yulia Haim, Tal Pecht, Roni Gat, Tanya Tarnovscki, Martin Gericke, Assaf Rudich
  Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids.2019; 1864(12): 158527.     CrossRef
• Autophagy and Age-Related Eye Diseases
  Xue Yang, Xinan Pan, Xiaorui Zhao, Jin Luo, Mingpu Xu, Daoming Bai, Yan Hu, Xu Liu, Qiongfang Yu, Dian Gao
  BioMed Research International.2019; 2019: 1.     CrossRef
• Foam cell formation and cholesterol trafficking and metabolism disturbances in atherosclerosis
  Alexandrina Volobueva, Dongwei Zhang, Andrey V. Grechko, Alexander N. Orekhov
  Cor et Vasa.2019; 61(1): 48.     CrossRef
• Oxidative Stress, Lipid Peroxidation, and Loss of Hyaluronic Acid in the Human Vitreous Affected by Synchysis Scintillans
  Loredana Bergandi, Oleksii A Skorokhod, Rosalba La Grotta, Evelin Schwarzer, Raffaele Nuzzi
  Journal of Ophthalmology.2019; 2019: 1.     CrossRef
• Programmed cell death protein 4 deficiency suppresses foam cell formation by activating autophagy in advanced glycation end‐product low‐density lipoprotein–induced macrophages
  Shan Li, Guangdong Gao, Fuyun Wu, Dan Liu, Hongyan Zhao, Jing Ke, Ying Liu, Fei Li, Jian Li, Zongyun Chen, Zhiming Tang, Lei Bai, Jinxuan Zhang, Wei Zheng, Xin Chen
  Journal of Cellular Biochemistry.2019; 120(5): 7689.     CrossRef
• Mindin deficiency in macrophages protects against foam cell formation and atherosclerosis by targeting LXR-β
  Cheng Zhang, Juan-Juan Qin, Fu-Han Gong, Jing-Jing Tong, Wen-Lin Cheng, Haiping Wang, Yan Zhang, Xueyong Zhu, Zhi-Gang She, Hao Xia, Li-Hua Zhu
  Clinical Science.2018; 132(11): 1199.     CrossRef
• LJ-1888, a selective antagonist for the A3 adenosine receptor, ameliorates the development of atherosclerosis and hypercholesterolemia in apolipoprotein E knock-out mice
  Jong-Gil Park, Se-Jin Jeong, Jinha Yu, Gyudong Kim, Lak Shin Jeong, Goo Taeg Oh
  BMB Reports.2018; 51(10): 520.     CrossRef
• Intracellular and Plasma Membrane Events in Cholesterol Transport and Homeostasis
  Dmitry Y. Litvinov, Eugeny V. Savushkin, Alexander D. Dergunov
  Journal of Lipids.2018; 2018: 1.     CrossRef